Exciting New FDA-Approved Nasal Epinephrine Spray for Anaphylaxis
Great news for those dealing with severe allergies! On August 9th, 2024, the FDA approved the first non-injection epinephrine delivery device to treat anaphylaxis, a life-threatening allergic reaction. This new nasal spray offers a needle-free option, which could be a game-changer for many patients, especially children and those with a fear of needles.
Why This Approval is a Big Deal
Traditionally, epinephrine has only been available via injection, which can be scary for many, particularly kids. The idea of self-administering an injection during a stressful allergic reaction can cause significant hesitation and fear. This new nasal spray addresses these concerns, providing a more user-friendly option.
How Epinephrine Works
Epinephrine is a medication that activates multiple receptors in the body to counteract the severe symptoms of anaphylaxis. Epinephrine helps reverse the drops in blood pressure, airway constriction, and other dangerous symptoms of anaphylaxis. We like to say “More than skin, Epi goes in!” Epinephrine is the antidote for any serious allergic reaction.
How the Nasal Spray Compares to Injections
Research has shown that the nasal spray is just as effective as the traditional auto-injectors in delivering epinephrine into the bloodstream. While the auto-injector may deliver the drug slightly faster in the first few minutes, the nasal spray provides comparable results overall.
Usage and Dosage
The nasal spray is designed for people weighing over 66 pounds (approximately 30 kilograms). Each spray delivers a 2 mg dose of epinephrine, similar in effectiveness to the 0.3 mg dose from auto-injectors. For those needing a second dose, the spray should be administered in the same nostril using a NEW device. They are intended to come in a package of two and cannot be reused.
Safety and Side Effects
Common mild side effects include throat irritation, nasal discomfort, and headache. Importantly, the nasal spray’s effectiveness isn’t hindered by common nasal issues like congestion from allergies. Studies even suggest faster absorption during a nasal allergic reaction.
Durability and Storage
The nasal spray has a shelf life of around 30 months and can withstand temperatures up to 122°F. If accidentally frozen, it can be thawed and still be effective, making it potentially more resilient than some auto-injectors. However, it is always recommended to keep at room temperature similar to the auto-injector.
Cost and Availability
Neffy is expected to be available in pharmacies by Thanksgiving 2024 and the nasal spray will be sold in twin packs. While exact pricing isn’t clear yet, patient assistance programs aim to keep out-of-pocket costs between $25 and $200.
What This Means for Patients
This new nasal spray option is likely to be welcomed enthusiastically by patients and their families. Though some may prefer to carry both the nasal spray and their auto-injector initially, many are excited about a needle-free alternative. Education and knowledge for use in schools and other environments will be key as this new option becomes more widespread.
The approval of this nasal spray is an exciting new option in the treatment for severe allergies. Again, it is always important to remind everyone that epinephrine is the treatment of choice and first line for anaphylaxis.
Allied Physicians Group is a partnership of more than 150 dedicated, caring physicians and 350 highly trained support staff. We offer pediatric care, family medicine, and other specialties at our practice locations. Allied Physicians Group has office locations in Brooklyn, Queens, Staten Island, Nassau, Suffolk, Westchester, Rockland, and Orange Counties. If you are looking for a physician near you click here, or for more information, please visit: https://alliedphysiciansgroup.com.